CHEWABLE Women's Sleep+ White Paper

Table of Contents

1. Introduction

At CHEWABLE SCIENCE, our approach to health is based on the belief that the body has an inherent capacity to regulate, adapt, and heal when given the right support. Rather than masking symptoms, we aim to address the underlying mechanisms that drive imbalance. Our formulations focus on uncovering root causes and supporting the body's natural pathways in a gentle, biologically aligned way.

We view modern care as a combination of natural and scientific approaches. We focus on women's health during perimenopause by strengthening resilience to symptoms caused by hormonal changes and the strain of modern life. Our mission is to help women find more health and build better lives through evidence-based and practical solutions.

We develop science-based resilience routines in the form of gummies. Our formulations are free from unnecessary additives and they are intended for consistent, long-term use. Our products are created for self-care to support positive habit building. Each gummy combines active ingredients chosen not only for their individual effects, but also for how they work together. We aim at reflecting nature's way of using synergy to enhance benefits.

This white paper outlines the rationale and formulation strategy behind CHEWABLE SCIENCE Women's Sleep+, a non-hormonal sleep solution built around phytomelatonin - a plant-based alternative to synthetic melatonin. Unlike conventional melatonin supplements that deliver the hormone in high doses, phytomelatonin works as a gentle regulator, supporting the body's own circadian rhythm and melatonin production.

While no supplement can reverse the hormonal changes every woman experiences, a well-targeted product that respects the natural hormonal rhythm can provide meaningful support. Our approach is to offer a plant-based sleep formula in gentle, synergistic doses that work with the body rather than override it.

We chose the gummy format because it not only makes bedtime routines easier, but also enhances absorption, starting in the mouth with a pleasant taste experience. A near liquid form helps deliver active compounds more efficiently, even in those with digestive and absorption challenges.

2. Why Sleep Quality Matters

This white paper was created to offer a science-based perspective on sleep in the context of women's health. While hormonal transitions will be discussed in more detail in Chapter 3, we begin from a more foundational point of view: sleep is a core regulator of physical, mental and emotional health.

True rest has become increasingly rare in today's constantly awake world. Our bodies sit still, but our minds rarely stop. The nervous system is locked in a persistent state of alertness and overstimulation. Notifications, deadlines, multitasking and emotional demands keep us in high gear, while recovery is postponed or bypassed entirely. Over time, this leads to a familiar state: feeling tired but wired at bedtime. The mind races even if the body is exhausted. This mismatch signals a deep dysregulation where the nervous system has forgotten how to downshift. When this becomes the norm, recovery suffers and the body loses the ability to reset at night. Eventually, the system gives in and exhaustion follows. Over time, this can contribute to metabolic dysfunction, impaired immune function and systemic inflammation that increase the risk of chronic conditions ranging from cardiovascular and metabolic disorders to mood-related issues and cognitive decline.

The ability to fall asleep, stay asleep and reach deep stages of rest is not just a nighttime concern. It is a fundamental regulator of biological rhythm. What often goes unrecognized is that sleep problems are rarely about sleep alone. Female reproductive hormones interact closely with the body's sleep-wake systems. Monthly hormonal changes alone can disrupt sleep, and those already struggling with sleep are more significantly impacted (de Zambotti, Colrain, and Baker, 2015). Estrogen and progesterone both play regulatory roles in sleep architecture and their decline in perimenopause is linked to increased nighttime awakenings and fragmented rest even in the absence of hot flashes or depressive symptoms (Coborn et al., 2022; Haufe and Leeners, 2023). This strain to the nervous system can impair the brain's ability to maintain a healthy circadian rhythm, which in turn is a double-edged sword, as sleep is one of the most essential regulators of hormonal balance.

Sleep can be seen as a biomarker of the body's capacity to compensate lifestyle strains; too much stress, too little time in parasympathetic mode, nutrient depletion or unresolved inflammation can all tip the body out of balance if sleep is not sufficient and restorative. In this light, healthy sleep becomes a necessary first step toward maintaining compensation capacity and increasing systemic well-being.

In recent years, the conversation around menopause has expanded with a growing recognition of how midlife women's health impacts their personal vitality, work capacity and overall sense of agency. The McKinsey Health Institute (2024) notes that women in this life stage often face significant inequities in symptom recognition, with sleep disturbances frequently go under-addressed despite their central role in health and quality of life (Benge, Pavlova and Javaheri, 2024).

3. Hormonal Shifts, Nervous System Overload and Sleep

The hormonal shifts of perimenopause and menopause represent one of the most disruptive phases in female sleep health. Declining estrogen and progesterone levels are not just linked to hot flashes and night sweats but also to more subtle, systemic effects that impact recovery and nervous system regulation (Nathan et al., 2017). Elevated follicle-stimulating hormone (FSH) levels during perimenopause have been associated with increased wakefulness after sleep onset and a higher number of nocturnal awakenings, highlighting the link between hormonal fluctuations and disrupted sleep architecture (de Zambotti, Colrain & Baker, 2015).

Progesterone has a calming effect on the brain by enhancing the activity of GABA (gamma-aminobutyric acid), the key inhibitory neurotransmitter responsible for relaxation and reduced neural excitability. As progesterone declines during perimenopause and in the late luteal phase of the menstrual cycle, sleep quality tends to suffer. Studies show that progesterone supplementation can reduce nighttime wakefulness and increase slow-wave sleep, the deep, restorative stage essential for physical and cognitive recovery (Caufriez et al., 2011).

Estrogen also plays a regulatory role, though its direct influence on sleep architecture is less consistent. Its broader impact lies in mood modulation, thermoregulation and protection against inflammation, which indirectly impact sleep quality. Beyond that, estrogen interacts with many systems throughout the body, with receptors found in the brain, joints, gut and cardiovascular tissue. This widespread presence helps explain why declining estrogen levels can lead to such a diverse array of symptoms, from joint pain and temperature dysregulation to shifts in the gut microbiome and increased emotional sensitivity. In fact, studies suggest that decreases in estrogen may contribute to the higher prevalence of depression and anxiety in women during midlife (Vigod and Stewart, 2009; Albert, 2015).

While night sweats are widely recognized, other sleep-disruptive effects of hormonal shifts, such as cognitive symptoms like brain fog or poor concentration, are often overlooked as hormonal in origin. These changes can undermine the body's ability to recover, increase inflammatory load and gradually turn resilient sleepers into chronic insomniacs. (Haver, 2024)

In addition to hormonal factors, modern life puts persistent strain on the nervous system. A high-stimulus environment with its constant notifications, blue light exposure and irregular routines, disrupts circadian rhythms and causes cortisol levels to spike during the day and even into the evening. Naturally, cortisol should peak in the morning to help us wake up, then steadily decline throughout the day to prepare the body for restful sleep at night. Overtraining, overworking and diets high in refined carbohydrates further challenge the body's ability to downshift into rest.

For many women, this nervous system overload remains manageable until hormonal buffering declines. Once estrogen and progesterone begin their uneven descent, the body's compensatory capacity weakens and previously occasional sleep issues become more frequent and stubborn. This tipping point is the moment when "sleep starts to deteriorate and what used to be rare becomes the norm." (Haver, 2024)

Sleep, when functioning well, is a powerful ally. During deep sleep, growth hormone is released to promote tissue repair, the glymphatic system clears waste from the brain and the autonomic nervous system recalibrates. But when these processes are disrupted, everything from immunity and metabolism to cognitive sharpness and emotional stability begins to erode.

4. The Growing Need for Sleep Support for Women

It goes without saying that lack of sleep negatively impacts quality of life. Short sleep duration and poor sleep quality have been linked to negative health outcomes, including a higher risk of weight gain and type 2 diabetes (Vézina-Im et al., 2017). More severely, the cumulative long-term effects of sleep disorders have been linked to a higher risk of serious health issues, such as high blood pressure, metabolic disorders, depression, heart attacks and strokes (Colten and Altevogt, 2006).

Sleep issues affect women disproportionately to men. Research consistently shows that women report higher rates of sleep disturbances across their lifespan compared to men. This increased vulnerability can be attributed to differences in neurobiology, hormonal fluctuations, heightened stress sensitivity and the cumulative effects of mood, lifestyle and socioeconomic factors. (El Rafihi-Ferreira et al., 2022, Zhang et al., 2022).

To make matters worse, sleep disorders in women are often overlooked or diagnosed later than in men, delaying effective care (Marsella and Sharkey, 2020). Additionally, the McKinsey Health Institute notes that, in general, women often face significant inequities in symptom recognition (McKinsey Health Institute, 2024). Therefore, it is essential to address sleep issues through a targeted lens; one that reflects the unique physiological and hormonal shifts women experience from puberty through menopause.

Good health is not built on quick fixes. Therefore, CHEWABLE SCIENCE wants to contribute to building meaningful and lasting improvements in women's health. With WOMEN'S SLEEP+, the focus is in supporting the body at the source of sleep problems, not in masking symptoms. Stress and hormone-related sleep symptoms can be present in women's lives for years, so support has to be sustainable and respectful of the body's delicate hormonal system. Instead of following the common trend of formulating the "strongest" or "most potent" blend, the aim was to create gentle stimulation that guides the body toward rest, rather than forcing it to shut down. Restoring the natural rhythm of sleep means addressing the root cause, and the welcome heaviness of sleep can finally give the body more stage over the racing mind. With smart dosing, WOMEN'S SLEEP+ helps restore the body's own vital mechanisms for rest and recovery.

As we explore the growing need for targeted support, it's important to shift how we think about the relationship between age and sleep. While sleep issues are often attributed to ageing, it's rarely ageing alone that disrupts the body's ability to rest and recover. More often, it is the slow accumulation of overstimulation, stress, hormonal shifts and lifestyle strain that build up silently and wear down the body's compensatory systems, until symptoms once managed in the background start surfacing as if ageing itself were a disease.

4.1 The Blind Spot in Women's Sleep Care

According to the American Psychiatric Association (2024), insomnia disorder is formally diagnosed when sleep difficulties, such as trouble falling asleep, staying asleep, or waking up feeling drowsy 1) occur at least three times per week for three months or more and 2) interfere with daytime functioning or cause distress. While this definition provides clinical structure, it often fails to capture the hormonally driven sleep disturbances many women face during perimenopause. In this life phase, sleep often becomes fragmented or irregular due to unpredictable fluctuations in estrogen and progesterone and the impact on daily life can be just as severe as with clinical insomnia, even though the formal diagnostic criteria are not met. This hormonal chaos, marked by sudden drops, surges and irregular rhythms, often creates symptoms that fall outside rigid diagnostic criteria. As a result, many women "fall through the net" of standard care and are left without targeted support for what is a very real, physiologically rooted disruption.

The clinical guidelines for insomnia emphasize chronicity and frequency, focusing heavily on behavioral and psychiatric causes. Evaluation typically includes a sleep history, lifestyle assessment, mental and physical health screening and diagnostic tests like EEG or ECG when indicated. But for midlife women, these criteria can create a significant blind spot. Hormonal sleep disruptions that are mainly triggered by fluctuating estrogen and progesterone may not present as textbook insomnia and are often intermittent, masked by other symptoms like anxiety or mood swings. As a result, many women are not taken seriously or are misdirected toward treatments that overlook the hormonal root of their sleep problems altogether. This delay in recognition and treatment leaves a large proportion of women without targeted, effective support at a time when their physiology is most in flux.

4.2 Common Medical Treatments for Sleep Problems

Common sleep aids, ranging from over-the-counter sedatives to synthetic melatonin, often address sleep in an unsustainable way. In addition, many of these medications carry risks of side effects, misuse and dependency (www.medicalnewstoday.com, 2022). What is often missing is an approach that supports the body's own regulatory systems; nervous system regulation and circadian rhythm.

When sleep medications are prescribed, they often reflect a general approach rather than one tailored to the underlying causes unique to midlife. Pharmacological treatments may help, but they carry side effects and should always be used under professional supervision. Many of the medications used to improve sleep during menopause are not actually sleep medications per se, but rather treatments for vasomotor symptoms like hot flashes, which are known to disrupt sleep. (Haver, 2024)

Menopausal hormone therapy (MHT) is one of the most common interventions. Though not indicated for treating primary insomnia, it is effective in reducing nighttime hot flashes, a major contributor to sleep fragmentation. Selective serotonin reuptake inhibitors (SSRIs) such as escitalopram and paroxetine and serotonin-norepinephrine reuptake inhibitors (SNRIs) like venlafaxine, are also used to reduce hot flashes and improve mood. GABAergic agents like gabapentin may ease nighttime awakenings. However, each of these medications comes with potential side effects such as dizziness, nausea, drowsiness, or in some cases, increased risk of dependency or cognitive changes if used long-term.

Newer classes of medications, like melatonin receptor agonists (e.g., ramelteon) and orexin receptor antagonists (e.g., suvorexant), target specific aspects of the sleep-wake cycle. While they show promise in helping with sleep onset and maintenance, they still do not address the hormonal and nervous system dysregulation that underpins sleep issues in many midlife women. (El Rafihi-Ferreira et al., 2022)

Current insomnia guidelines caution against the long-term use of pharmacological treatments, recommending them only when non-drug approaches like CBT-I (Cognitive Behavioral Therapy for Insomnia) are unavailable or ineffective. This points to a persistent gap in care: conventional treatments often fail to recognize the underlying biology of perimenopausal insomnia. For women whose sleep has become disrupted not because of poor sleep hygiene or anxiety, but because their hormonal rhythm has shifted, the standard approaches may fall short. Addressing sleep in midlife calls for more than sedation. It requires a deeper understanding of how female physiology interacts with rest, resilience and recovery.

4.3 The Modern Way: Treating the Root Cause

Addressing female sleep disruption requires more than short-term solutions. Many conventional sleep aids simply sedate without supporting the body's deeper processes of adaptation and repair. In contrast, CHEWABLE SCIENCE's approach is rooted in a compensatory model: rather than masking symptoms, we aim to support the body in adapting to hormonal shifts using a multipathway approach.

This is especially critical given that hormonal transitions can take 7 to 10 years to stabilize. A woman may not yet be menopausal, but her sleep may already be affected by the steep drop in progesterone during the late luteal phase of her cycle. Supporting the circadian signaling is therefore relevant across the full spectrum, from the first signs of perimenopause to the years after menopause.

The CHEWABLE SCIENCE Women's Sleep+ was designed with this need in mind. It offers nutritional support for the pathways most disrupted during hormonal shifts, especially those tied to relaxation, neurotransmitter balance and cellular recovery.

Understanding sleep problems through a female lens is essential, because on top of external stress and modern lifestyle overload, women's sleep cycles are affected by hormonal rhythms that shift across the menstrual cycle, pregnancy, perimenopause and beyond. Generic sleep aids often miss this holistic approach. Solutions that take into account the delicate hormonal balance and its connection to neural signaling in the female body provide targeted support to the body's natural recovery processes. Targeted care is not just more helpful than generic aids, but it is necessary for maintaining good health.

4.4 Building and Maintaining Compensation Capacity

Health is not only about avoiding illness, but about having the capacity to cope with what life throws at you. This "compensation capacity" means that your body can handle stressors, reset back to baseline and keep its balance even when challenged.

What protects this balance are the body's fundamental rhythms; hormonal cycles, the cortisol rhythm, the sleep-wake rhythm, even the glucose-insulin cycle. Together they form the baseline that allows the body to function, adapt, recover and repeat.

Sleep and recovery lie at the very heart of this system. When sleep is disrupted, the body loses one of its main ways of maintaining compensation capacity. What makes especially women more vulnerable, are hormonal fluctuations. They add an extra layer of challenge, amplifying the impact of external stressors. But this trajectory does not have to be inevitable. With the right kind of support, these rhythms can be stabilized and strengthened.

That is why the CHEWABLE SCIENCE Women's Sleep+ is not just designed to help with "falling asleep" - even if that is the first noticeable effect. Our goal is to provide gentle, long-term support for the body's own cycles, helping women maintain resilience, restore health, and live well over time.

5. The Multipathway Approach

Poor sleep not only makes you feel tired. It disrupts the way your body restores itself, regulates mood and manages stress and hormones. The formulation of CHEWABLE SCIENCE Women's Sleep+ is designed to target these challenges from several angles rather than just forcing sleep with sedatives or high-dose synthetic melatonin. It supports pathways involved in falling asleep, staying asleep and restoring the body's ability to recover.

The formulation addresses all areas of sleep and recovery:

5.1 Sleep Onset

The CHEWABLE SCIENCE Women's Sleep+ gummy is designed to support the natural initiation of sleep by working with the body's circadian rhythm and melatonin pathways. Phytomelatonin gently interacts with melatonin receptors without overriding the body's own production, making it more suitable for consistent, long-term use compared with high-dose synthetic melatonin.

When falling asleep is delayed or disrupted, many people unconsciously compensate the following day by consuming stimulants, often later in the afternoon or evening, to counteract fatigue. This creates a self-perpetuating cycle: late stimulant use delays melatonin release and further disrupts natural sleep onset. Supporting the body's own signals for sleep reduces this compensatory reliance, helping to re-establish a more stable sleep-wake rhythm over time.

5.2 Restorative Sleep

Deep sleep is when the body performs most of its repair and regeneration processes, from nervous system recalibration to tissue and cellular repair. The formulation supports these processes by encouraging deeper sleep phases and enhancing physiological recovery. Melatonin contributes to reducing oxidative stress and protecting cells, helping the body maximize restoration overnight. Effective deep sleep is essential, as insufficient restoration can gradually impair cognitive, hormonal and physical resilience.

5.3 Deep Sleep

Waking up at night, often several times per night and inability to fall back asleep easily are among the most disruptive and commonly reported sleep issues during perimenopause. These interruptions are typically more difficult to address than delayed sleep onset, as they are closely linked to hormonal fluctuations, particularly cortisol, but also blood sugar regulation. By supporting the body's natural sleep-wake cycle, the formulation helps reduce these nighttime awakenings. Regular use can lead to more consistent, uninterrupted sleep. Sustained sleep contributes to improved mood, increased daytime energy and overall cognitive and emotional resilience.

5.4 Nervous System Regulation

A stable sleep-wake cycle allows the nervous system to maintain flexibility, responding effectively to daily stress without overreactions while still enabling a natural overnight reset. Over time, improved nervous system balance helps stabilize various symptoms that are linked to fluctuating hormone levels during perimenopause and midlife transitions.

5.5 Long-term Benefits of Restorative Sleep

Good sleep is more than rest; it is a cornerstone of metabolic, immune and emotional health. Chronic low-grade inflammation interferes with sleep quality by disrupting neurotransmitter function and increasing nervous system activation. The CHEWABLE SCIENCE Women's Sleep+ includes compounds that help calm inflammatory pathways and support immune balance. Over weeks and months, consistent high-quality sleep supports appetite regulation, weight management and even immune functions, while melatonin reduces oxidative stress and inflammation (Millán-Plano et al., 2010), freeing the body's capacity for deeper recovery.

6. Ingredient Functions

The CHEWABLE SCIENCE Women's Sleep+ formulation is built around phytomelatonin as the principal active, with additional compounds included in supporting roles that together form a synergistic framework. Rather than relying on high doses of a single substance, the design follows a synergy model: smaller amounts of complementary nutrients are combined to influence different stages of sleep regulation, absorption, and recovery.

Main active

  • Phytomelatonin (250 mcg) - derived from plant sources (St. John's wort). As the core active, it provides a gentle signal to initiate sleep while respecting endogenous melatonin rhythms, rather than suppressing the body's own production.

Supporting actives

  • Aquamin magnesium (1 mg) - a marine-derived mineral complex that contributes to nervous system regulation and enzymatic activity involved in cellular recovery.
  • GABA (plant-derived, 1.5 mg) - an inhibitory neurotransmitter that promotes relaxation and supports the nervous system's transition into night mode.
  • L-tryptophan (plant-derived, 1.5 mg) - an essential amino acid and precursor of serotonin and melatonin, indirectly contributing to mood balance and sleep regulation.
  • Fulvic acid minerals (430 mcg) - a naturally occurring complex of trace minerals thought to enhance cellular transport and bioavailability of other nutrients.

In CHEWABLE SCIENCE formulations, the focus is on synergy over quantity. The efficacy of Women's Sleep+ relies on the biochemical context in which phytomelatonin is delivered. Inspired by natural plant matrices, the formulation uses a complementary blend of supporting compounds intended to facilitate recognition, transport, and integration of the ingredients. This approach is particularly relevant for perimenopausal women, whose hormonal fluctuations make the system more sensitive.

Multi-ingredient formulas often achieve effects at lower doses per component due to complementary mechanisms. Compounds such as fulvic acid minerals and Aquamin magnesium may act as cofactors, supporting cellular uptake and functional activity. This allows microdosing of potent actives like phytomelatonin, GABA, and L-tryptophan in a way that aligns with the body's inherent mechanisms, based on current understanding of physiology and clinical experience. By mimicking nature's "phytonutrient cocktail," the formulation is intended to enhance the potential effects of each active while maintaining harmony with female physiology, supporting sleep and recovery without unnecessary metabolic strain.

Each ingredient in CHEWABLE SCIENCE Women's Sleep+ plays a specific role within this synergistic framework. While individually they influence particular aspects of sleep and recovery, together they are designed to produce multi-pathway support for natural processes. The following sections outline the key functions, mechanisms of action, and potential health benefits of each active, highlighting their contributions to sleep onset, deeper restoration, overnight continuity, and circadian rhythm stabilization.

6.1 Phytomelatonin

Phytomelatonin is chemically identical to melatonin produced by the body but derived from plants such as St. John's wort. Melatonin is widely recognized as a key regulator of the circadian rhythm, including the core body temperature cycle that underlies sleep initiation and maintenance (Megha et al., 2024), (Cagnacci, Elliott and Yen, 1992). Phytomelatonin is chemically identical to human melatonin and therefore interacts with the same receptors and pathways. This structural identity allows the same physiological claims to be applied: supporting the natural sleep-wake cycle, aligning circadian signals, and facilitating sleep onset. When used in physiologically relevant doses, the body's endogenous melatonin production is preserved. Disruptions in melatonin production or timing can lead to sleep and circadian rhythm disorders. (Vasey, McBride and Penta, 2021).

Unlike synthetic melatonin, which may contain chemical residues, phytomelatonin is produced naturally without toxic solvents. This ensures a clean extract, but also that important plant compounds, that improve phytomelatonin's bioavailability, are preserved. Synthetic melatonin can saturate the melatonin receptors of cells over time (Sweis, 2005), but phytomelatonin is better tolerated and more sustainable for long-term use.

Phytomelatonin (80-300 µg) from plant sources have shown measurable improvements in sleep duration (Howatson et al., 2011), (Yurcheshen, Seehuus and Pigeon, 2015). It demonstrates stronger antioxidant and anti-inflammatory activity compared with synthetic melatonin (Reiter et al., 1999). Nighttime melatonin production naturally declines with age, particularly in women during perimenopause, making supplementation at physiological doses beneficial.

Primary functions: Regulates circadian rhythm, supports sleep onset and quality, antioxidant and anti-inflammatory activity, contributes to tissue repair.

Mechanisms of action: Aligns with natural physiology by binding to melatonin receptors, adjusts the internal clock without suppressing endogenous melatonin production.

Supports: Falling asleep, circadian rhythm alignment, metabolism, stress resilience, immune function. (Reiter et al., 2016)

6.2 Aquamin Magnesium

Aquamin is a marine-derived magnesium complex providing 12% elemental magnesium along with more than 70 naturally occurring trace minerals. It has superior solubility and intestinal absorption facilitating absorption without gastrointestinal discomfort often connected to commonly used forms such as magnesium bisglycinate (Dowley et al., 2024). Enhanced solubility is directly linked to mineral bioavailability. Trace minerals synergistically support cellular health and nutrient uptake, contributing to calmer nervous system activity.

Primary functions: Nervous system regulation, cellular balance through mineral replenishment.

Mechanisms of action: Supporting GABAergic pathways and overall mineral balance.

Supports: Reduced neural excitability, improved sleep quality, decreased nighttime restlessness.

6.3 Gamma-Aminobutyric Acid (GABA)

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, responsible for reducing neuronal excitability and promoting a state of calm. In the CHEWABLE SCIENCE Women's Sleep+ formulation, GABA is derived from plant sources. Clinical research indicates that natural GABA can reduce sleep latency even at relatively low doses (Yoon, Byun and Won Chul Shin, 2022). As low-dose GABA primarily supports the initiation of sleep rather than its maintenance, it is suitable for formulations that combine multiple pathways for comprehensive sleep support.

Primary functions: Inhibitory neurotransmitter support, calming effect, promotes nervous system downshift.

Mechanisms of action: Activates GABA-A receptors, reducing neuronal excitability and indirectly modulating parasympathetic tone.

Supports: Reduced nervous tension, facilitation of sleep onset.

6.4 L-Tryptophan

L-tryptophan is an essential amino acid and a precursor for the synthesis of serotonin and melatonin, key regulators of mood and sleep-wake cycles. In the CHEWABLE SCIENCE Women's Sleep+ formulation, it supports the body's natural production of these neurotransmitters, helping align circadian rhythms and promote restful sleep. Dietary tryptophan reduces sleep onset latency and supports uninterrupted sleep. Deficiency is linked to sleep fragmentation and emotional dysregulation. (Hartmann, Chung and Chien, 1971)

Primary functions: Precursor to serotonin and melatonin, supporting sleep and mood regulation.

Mechanisms of action: Converted to 5-HTP and serotonin, then melatonin; influences circadian rhythm and emotional balance.

Supports: Sleep-wake rhythm, mood stability, deeper restorative sleep.

6.5 Fulvic Acid

Fulvic acids are water-soluble organic polymers that naturally occur as components of humic substances. They are formed during the decomposition of plant material, resulting in a complex structure containing over 70 minerals, amino acids and plant derivatives. Due to their ionic nature, fulvic acids are excellent conductors of electricity, enhancing the absorption and transport of other nutrients (Murbach et al., 2020). Fulvic acid binds to essential minerals and trace elements such as calcium, magnesium, and potassium, facilitating their transport and uptake within the gastrointestinal tract. This improved bioavailability ensures that nutrients are effectively utilized. (Konnova et al., 2023)

Primary functions: Enhances nutrient bioavailability, supports cellular level function.

Mechanisms of action: Facilitates transport of minerals and amino acids, modulates oxidative stress and inflammation, supports mitochondrial function.

Supports: Cellular regeneration, efficient nutrient utilization.

Disclaimer

The information presented in this paper is based on publicly available data regarding ingredients and is intended for informational purposes only. It is not intended for marketing health claims or as a substitute for professional medical advice.

In the development of Women's Sleep+, we respect each individual's personal decision regarding the use of hormone replacement therapy (HRT) and do not seek to influence or sway that choice. However, this product has been designed to be compatible with HRT and can be used in conjunction with it.

This supplement has been developed with the intention of being suitable for a broad spectrum of users. Specific vitamins or herbs have been purposefully excluded to avoid potential contraindications with other supplements or medications.

While we acknowledge that perimenopause symptoms primarily stem from the decline in female hormone levels, no supplement can replace their hormonal effects.

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